GWAS
The digenysis™ Approach: The genetic analysis of both allele variation and copy number
Diagenesis (root word) – a recombination of the constituents resulting in a new product. The basic methodology of digenysis is a rigorous statistical approach that begins with the primary constituents of the study: the array measurements of the two alleles of each SNP. However, with digenysis, these measurements are not used to call genotypes. Instead, digenysis recombines and transforms these allele measurements into values that contrast as well as summarize the allelic intensities. It then performs statistical tests for allelic and copy number association directly while simultaneously accounting for latent factors such as subpopulation and processing biases. This figure provides an overview of the standard analysis process flow and the alternative flow of digenysis:
