Expression Analysis works with our clients, platform partners and microarray colleagues in order to optimize genomic protocols and improve data quality.

arrayCGH for Copy Number Variation

Dr. Reid is an invited member of the Microarray Research Group (MARG) within the Association of Biomedical Resource Facilities, which performs annual research projects to assess technological and analytical advancements.  The 2007 MARG research project compared results from five arrayCGH platforms.  Dr. Reid presented the results of this study at the Discovery-2-Diagnostics conference in September 2007.

Click here for presentation, Comparison of arrayCGH Platforms by the ABRF Microarray Research Group

Alternative Labeling Protocols for Challenging Specimens

Expression Analysis has collaborated with NuGEN Technologies to confirm the utility of the RiboSPIA labeling method on several challenging specimens, including limited RNA samples, whole blood, and formalin-fixed paraffin-embedded tissues.

Read press release, Expression Analysis Adopts NuGEN’s System for Small-Sample Amplification

Read press release, Expression Analysis is First Provider of NuGEN's Solution for FFPE Specimens

Globin RNA Reduction Protocols

RNA isolated from whole blood specimens contains an abundance of globin RNA transcripts, which may reduced sensitivity in microarray expression studies.  As a beta test site, Expression Analysis demonstrated the usefulness of an alternative protocol from Affymetrix and PreAnalytiX that relies on peptide nucleic acid oligomers to reduce globin transcripts in blood-derived specimens.

Click here for technical note, Globin RNA Reduction in Blood Samples for Affymetrix GeneChips

Click here for technical note, Expression Profiling of Whole Blood Specimens on Illumina BeadChips