RNA - microRNA
Focused Set
These recently discovered short RNA transcripts (21–22 nucleotides long) have been identified in diverse organisms, and are thought to be post-transcriptional modulators of gene expression. Current estimates are that as many as 30% of mammalian genes are regulated by miRNA. Regulation by miRNA has been shown to be an essential mechanism contributing to normal cell physiology and cellular developmental. There have been many descriptions of miRNA dysregulation implicated in the etiology and progression of disease of including cancer. Illumina has created two fixed panels of miRNA assays, one for human and one for mouse. Both panels assay a complete and broad spectrum of miRNA. The Human and Mouse MicroRNA panels quantitate the levels of 1146 or 656 miRNA, respectively and represent approximately 97% of known miRNAs (described in the Sanger Institute’s miRBase Release 12.05), plus additional novel content derived using Illumina sequencing technology.
Human v2 MicroRNA Expression Profiling